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The research on NAC is the most powerful on this front and you should check out our NAC and addiction review

[1] Berberine is a bioactive alkaloid compound extracted from several plants, including Berberis species (barberry), goldenseal, and Chinese goldthread

As noted by the Alzheimers Drug Discovery Foundation (ADDF), the bulk of research involving epithalamin and epithalon has been conducted in Russia (or formerly, the Soviet Union) and has not been subject to independent confirmation [1]

The Phase 2 trial data showed nausea in roughly 28% of patients at the 12mg dose, diarrhea in 24%, vomiting in 17%, and constipation in 11%

Microbiology 111(2):313326